The PCs are from a small settlement (approx 20 people) in Poluaski Park. The village elder asked them to travel to the nearby Super-Duper mart, where she had heard that there was a radroach nest. Glenn (the party healer/chem dealer) is deathly afraid of radroaches, but reluctantly agreed, because the village needed the meat.
After an uneventful trip to the Super Duper mart, the PCs found and dispatched nine radroaches, giving them enough meat to sustain the village for a little while. They also took out some feral ghouls and managed to scavenge some supplies from the place. However, upon returning to their home, they found it ransacked and completely devoid of people (or bodies)
At a loss for what ha happened or what to do, a Trader came to the village, unaware of what had happened. This trader (Jackson) was also at a loss for what might cause this, but suggested the PCs visit one of the largest settlements in Chicago; Thousand. Thousand, he explained, is a massive trade hub, and there might be information there. He agreed to hire on the PCs as guards for his caravan, and the PCs, with no other options, accepted.